3-Ethyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one → 3-Cyclopropyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one

HRID 1848497Notes

Reaction equation

HRID 1848497 reaction equation
[CH:1]1([C:4](=C)[CH2:5][C:6]2([C:19]([O:21]CC)=O)[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)[CH2:3][CH2:2]1.C(C1CC2(CCNCC2)C(=O)[N:28]1[C:38]1[CH2:39][O:40][C:41](=[O:43])[CH:42]=1)C>>[CH:1]1([CH:4]2[CH2:5][C:6]3([CH2:7][CH2:8][NH:9][CH2:10][CH2:11]3)[C:19](=[O:21])[N:28]2[C:38]2[CH2:39][O:40][C:41](=[O:43])[CH:42]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 867095063-Ethyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-oneHCID 867095071-Tert-butyl 4-ethyl 4-(2-cyclopropylallyl)piperidine-1,4-dicarboxylate

Product 1

HCID 867095083-Cyclopropyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one

Procedure

The title compound was prepared from 1-tert-butyl 4-ethyl 4-(2-cyclopropylallyl)piperidine-1,4-dicarboxylate in four steps in an analogous fashion as described for 3-ethyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one (I-43).

Sources & evidence

ORD record
ord-aa3edea55ad74c7da57cbd0179d04996
Source dataset
uspto-grants-2015_02
Patent number
US08952166B2

Reaction notes

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