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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1848497Generated: November 2, 2026

3-Ethyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one → 3-Cyclopropyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one

https://huagongshe.com/reaction/1848497

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Ethyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-oneHCID 86709506—
Reactant1-Tert-butyl 4-ethyl 4-(2-cyclopropylallyl)piperidine-1,4-dicarboxylateHCID 86709507—
Product3-Cyclopropyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-oneHCID 86709508—

Reaction Steps

The title compound was prepared from 1-tert-butyl 4-ethyl 4-(2-cyclopropylallyl)piperidine-1,4-dicarboxylate in four steps in an analogous fashion as described for 3-ethyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one (I-43).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08952166B2
Source datasetuspto-grants-2015_02
ORD IDord-aa3edea55ad74c7da57cbd0179d04996
Source noteuspto-grants-2015_02