1-Amino-2-propanol → 1-((4-Chlorophenethyl)amino)propan-2-ol

Temperature

120 °C

1-Aminopropan-2-ol (60.0 g, 799 mmol) was charged to a 250-mL round-bottom flask equipped with a magnetic stir bar, a thermocouple, a condenser, and a nitrogen bubbler vented to a caustic scrubber, and heated to 120° C. To this was slowly added the toluene solution of 1-chloro-4-(2-chloroethyl)benzene from Step A while maintaining the reaction temperature at 120-125° C. On completion of the addition, stirring was continued at 115-120° C. for 2.5 h. NaOH (50%, 12.78 g, 160 mmol) was added followed by water (25 mL) and the mixture was stirred at 70 to 75° C. for 15 min. The organic phase was separated and washed with water (4×25 mL) at 70 to 75° C. The combined aqueous phases were extracted with toluene (38 mL) for 15 min at 70 to 75° C. Then, the combined organic phases were concentrated under reduced pressure at 60° C. (bath). The residue was diluted with toluene to a total volume of 104 mL and the golden solution was stirred overnight at 50° C. (bath) under nitrogen. Karl Fischer titration showed 0.052% water.

1. customequipped with a magnetic stir bar
2. temperaturewhile maintaining the reaction temperature at 120-125° C
3. additionOn completion of the addition
4. stirringthe mixture was stirred at 70 to 75° C. for 15 min
5. customThe organic phase was separated
6. washwashed with water (4×25 mL) at 70 to 75° C
7. extractionThe combined aqueous phases were extracted with toluene (38 mL) for 15 min at 70 to 75° C
8. concentrationThen, the combined organic phases were concentrated under reduced pressure at 60° C. (bath)
9. additionThe residue was diluted with toluene to a total volume of 104 mL
10. stirringthe golden solution was stirred overnight at 50° C. (bath) under nitrogen

ORD record

ord-8dd189757e00492fa0eff4eccf4ede10

Source dataset

uspto-grants-2015_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08952197B2