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HRID1848785

反应详情

EQUATION

反应方程式

HRID 1848785 的结构方程式

REACTANTS

反应物

1
结构：Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1.O
HCID46869922

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)OC(=O)C[C@@H]2COc3cc(OCc4cccc(-c5c(C)cc(OCCCS(C)(=O)=O)cc5C)c4)ccc32)c1
HCID86706790

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

CONDITIONS

反应条件

温度
55 °C

PROCEDURE

实验过程

[(3S)-6-({2′,6′-Dimethyl-4′-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid hydrate (0.5 hydrate) (100 mg) was dissolved in 2-propanol (2.5 mL) at 55° C. After filtration, n-heptane (2.5 mL) heated to 55° C. was added, and the mixture was allowed to gradually cool to 5° C. with stirring. The precipitated crystals were collected by filtration to give [(3S)-6-({2′,6′-dimethyl-4′-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid anhydride as crystals (A form crystal) (about 60 mg).

WORKUP

后处理

  1. filtrationAfter filtration, n-heptane (2.5 mL)
  2. additionwas added
  3. temperatureto gradually cool to 5° C.
  4. filtrationThe precipitated crystals were collected by filtration