(R)-1-Phenylpropylamine → HCID 86706792, compound

HRID 1848795Notes

Reaction equation

HRID 1848795 reaction equation
[OH:1][C:2]1[CH:14]=[CH:13][C:5]2[CH:6]([CH2:9][C:10]([OH:12])=[O:11])[CH2:7][O:8][C:4]=2[CH:3]=1.[C:15]1([C@H:21]([NH2:24])[CH2:22][CH3:23])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CO>[C:15]1([C@H:21]([NH2:24])[CH2:22][CH3:23])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[OH:1][C:2]1[CH:14]=[CH:13][C:5]2[C@H:6]([CH2:9][C:10]([OH:12])=[O:11])[CH2:7][O:8][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 5324978(R)-1-PhenylpropylamineHCID 23111800(6-Hydroxy-2,3-dihydro-1-benzofuran-3-yl)acetic acid

Product 1

HCID 86706792HCID 86706792, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A racemate (19 mg, 0.1 mmol) of (6-hydroxy-2,3-dihydro-1-benzofuran-3-yl)acetic acid was charged, methanol was added, and the racemate was dissolved. The solution and ((R)-1-phenylpropylamine (13.5 mg, 0.1 mmol) were mixed and stood. The precipitated crystals were collected by filtration to give the title compound. 5.1% de

Workup

  1. dissolutionthe racemate was dissolved
  2. filtrationThe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-b638a57d7f394ac0aca74e38ca57cee7
Source dataset
uspto-grants-2015_02
Patent number
US08952185B2

Reaction notes

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