2-Pyrrolidinemethanol, alpha,alpha-diphenyl-, (R)- → HCID 86706793, compound

HRID 1848796Notes

Reaction equation

HRID 1848796 reaction equation
[OH:1][C:2]1[CH:14]=[CH:13][C:5]2[CH:6]([CH2:9][C:10]([OH:12])=[O:11])[CH2:7][O:8][C:4]=2[CH:3]=1.[C:15]1([C:21]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)([C@H:23]2[CH2:27][CH2:26][CH2:25][NH:24]2)[OH:22])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CO>[C:15]1([C:21]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)([C@H:23]2[CH2:27][CH2:26][CH2:25][NH:24]2)[OH:22])[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1.[OH:1][C:2]1[CH:14]=[CH:13][C:5]2[C@H:6]([CH2:9][C:10]([OH:12])=[O:11])[CH2:7][O:8][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 70453712-Pyrrolidinemethanol, alpha,alpha-diphenyl-, (R)-HCID 23111800(6-Hydroxy-2,3-dihydro-1-benzofuran-3-yl)acetic acid

Product 1

HCID 86706793HCID 86706793, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A racemate (19 mg, 0.1 mmol) of (6-hydroxy-2,3-dihydro-1-benzofuran-3-yl)acetic acid was charged, methanol was added, and the racemate was dissolved. This solution and (R)-α,α-diphenyl-2-pyrrolidinemethanol (25.3 mg, 0.1 mmol) were mixed and stood. The precipitated crystals were collected by filtration to give the title compound. 9.9% de

Workup

  1. dissolutionthe racemate was dissolved
  2. filtrationThe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-56a460c301264808a294758634b608c3
Source dataset
uspto-grants-2015_02
Patent number
US08952185B2

Reaction notes

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