反应详情

Benzoylacetonitrile (25 g, 0.17 mol) was suspended in a mixture of 125 mL reagent grade anhydrous alcohol and 20 mL glacial acetic acid. 2-Hydroxyethylhydrazine (14.4 g, 1.1 equiv) dissolved in 35 mL alcohol was added all at once. The mixture was heated at reflux for 4 h, cooled, water was added to make 500 mL total volume and the solution was chilled in a refrigerator overnight. Crystals were filtered cold on a Buchner funnel, washed with cold water and dried on high vacuum to give the desired product (27.2 g, 79%).

1. additionwas added all at once
2. temperatureThe mixture was heated
3. temperatureat reflux for 4 h
4. temperaturecooled
5. temperaturethe solution was chilled in a refrigerator overnight
6. filtrationCrystals were filtered cold on a Buchner funnel
7. washwashed with cold water
8. customdried on high vacuum