Chlorosuccinimide → HCID 68666651, compound

HRID 1848869Notes

Reaction equation

HRID 1848869 reaction equation
[Cl:1]N1C(=O)CCC1=O.[NH:9]1[C:17]2[C:12](=[CH:13][C:14]([O:18][C:19]3[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:20]=3[C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:15][CH:16]=2)[CH:11]=[CH:10]1>C1(C)C=CC=CC=1>[Cl:1][C:11]1[C:12]2[C:17](=[CH:16][CH:15]=[C:14]([O:18][C:19]3[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:20]=3[C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH:13]=2)[NH:9][CH:10]=1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 67145179HCID 67145179, compound

Product 1

HCID 68666651HCID 68666651, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

N-Chloro-succinimide (160 mg) was added portionwise to a solution of EXAMPLE 265A (300 mg) in toluene (10 mL) and the mixture was stirred at room temperature for about two hours. The mixture was chromatographed on a silica gel column with 30% ethyl acetate in hexane to give the title compound.

Workup

  1. customThe mixture was chromatographed on a silica gel column with 30% ethyl acetate in hexane

Sources & evidence

ORD record
ord-e7bc75da1177452eb5b5cbab298e1593
Source dataset
uspto-grants-2015_02
Patent number
US08952157B2

Reaction notes

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