反应详情

Methyl 2,4-difluorobenzoate (1.53 g), K3PO4 (1.89 g) and 4-hydroxyindole (1.08 g) were stirred at 110° C. in diglyme (12 mL) for 24 hours. The reaction was cooled and poured into ether. The solution was washed three times with 1 M aqueous NaOH solution, and brine, and dried over Na2SO4. The solution was then concentrated, and the crude product was chromatographed on silica gel with 20% ethyl acetate/hexanes.

1. temperatureThe reaction was cooled
2. washThe solution was washed three times with 1 M aqueous NaOH solution, and brine
3. dry with materialdried over Na2SO4
4. concentrationThe solution was then concentrated
5. customthe crude product was chromatographed on silica gel with 20% ethyl acetate/hexanes