Trifluoroacetic acid → HCID 178511076, compound

HRID 1848940Notes

Reaction equation

HRID 1848940 reaction equation
[C:1]([CH2:3][C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10][NH:11]C(=O)OC(C)(C)C)[CH2:6][CH2:5]1)#[N:2].FC(F)(F)C(O)=O>ClCCl>[NH2:11][CH2:10][C@H:7]1[CH2:8][CH2:9][C@H:4]([CH2:3][C:1]#[N:2])[CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178453593HCID 178453593, compound

Product 1

HCID 178511076HCID 178511076, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl (trans-4-(cyanomethyl)cyclohexyl)methylcarbamate (500 mg) in dichloromethane (5 mL) was slowly added trifluoroacetic acid (3 mL) at 0° C. The mixture was warmed to room temperature, stirred for 1 hour and concentrated. The residue was dried under vacuum to provide the title compound.

Workup

  1. customat 0° C
  2. concentrationconcentrated
  3. customThe residue was dried under vacuum

Sources & evidence

ORD record
ord-eaecf07e76bc48aab610871b166e2983
Source dataset
uspto-grants-2015_02
Patent number
US08952157B2

Reaction notes

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