1-(Tetrahydro-2-furoyl)piperazine → HCID 58203896, compound

HRID 1849113Notes

Reaction equation

HRID 1849113 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18](O)=[O:19])[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:3]=[N:2]1.[N:23]1([C:29]([CH:31]2[CH2:35][CH2:34][CH2:33][O:32]2)=[O:30])[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[NH:1]1[CH:5]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18]([N:26]5[CH2:27][CH2:28][N:23]([C:29]([C@H:31]6[CH2:35][CH2:34][CH2:33][O:32]6)=[O:30])[CH2:24][CH2:25]5)=[O:19])[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 27346411-(Tetrahydro-2-furoyl)piperazineHCID 582038838-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid

Product 1

HCID 58203896HCID 58203896, compound

Procedure

Following the procedure for 103, 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (50.0 mg, 0.2 mmol) was reacted with piperazin-1-yl(tetrahydrofuran-2-yl)methanone (1.2 equiv) to give 184 (19.3 mg, M+1 480.1)

Sources & evidence

ORD record
ord-4409e8510cbd4d8bbe34a2deff044e68
Source dataset
uspto-grants-2015_02
Patent number
US08952043B2

Reaction notes

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