5-Chloro-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoic acid → Tert-butyl 5-chloro-4-(cyclohexylmethoxy)-2-fluorobenzoate
Reaction equation
[Cl:1][C:2]1[C:3]([O:12][CH2:13][C:14]2(C(F)(F)F)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[CH:4][C:5]([F:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].ClC1C(OCC2CCCCC2)=C[C:28](F)=[C:29]([CH:33]=1)[C:30](O)=O>>[Cl:1][C:2]1[C:3]([O:12][CH2:13][CH:14]2[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]2)=[CH:4][C:5]([F:11])=[C:6]([CH:10]=1)[C:7]([O:9][C:29]([CH3:33])([CH3:30])[CH3:28])=[O:8]Participants
3
Procedure
Following the procedure as described in Example 158 step 2 and making variations as required to replace 5-chloro-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoic acid with 5-chloro-4-(cyclohexylmethoxy)-2-fluorobenzoic acid, the title compound was obtained as a colorless oil (15.37 g, 43%): MS (ES+) m/z 381.2 (M+39).
Sources & evidence
- ORD record
- ord-d36efc80a6c54d4cbad977af3ed2b1dc
- Source dataset
- uspto-grants-2015_02
- Patent number
- US08952169B2
Reaction notes
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