HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoic acid → Tert-butyl 5-chloro-4-(cyclohexylmethoxy)-2-fluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoic acid | HCID 86703446 | — |
| Reactant | 5-Chloro-4-(cyclohexylmethoxy)-2-fluorobenzoic acid | HCID 86703485 | — |
| Product | Tert-butyl 5-chloro-4-(cyclohexylmethoxy)-2-fluorobenzoate | HCID 86703484 | — |
Reaction Steps
Following the procedure as described in Example 158 step 2 and making variations as required to replace 5-chloro-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoic acid with 5-chloro-4-(cyclohexylmethoxy)-2-fluorobenzoic acid, the title compound was obtained as a colorless oil (15.37 g, 43%): MS (ES+) m/z 381.2 (M+39).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952169B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-d36efc80a6c54d4cbad977af3ed2b1dc |
| Source note | uspto-grants-2015_02 |