Tert-butyl 5-chloro-2-fluoro-4-((1-(trifluoromethyl)-cyclohexyl)methoxy)benzoate → Tert-butyl 4-(cyclohexylmethoxy)-5-cyclopropyl-2-fluorobenzoate

HRID 1849628Notes

Reaction equation

HRID 1849628 reaction equation
Cl[C:2]1[C:3]([O:16][CH2:17][C:18]2(C(F)(F)F)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[CH:4][C:5]([F:15])=[C:6]([CH:14]=1)[C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8].ClC1C(OCC2CCCCC2)=C[C:32](F)=[C:33]([CH:41]=1)C(OC(C)(C)C)=O>>[CH:18]1([CH2:17][O:16][C:3]2[C:2]([CH:41]3[CH2:33][CH2:32]3)=[CH:14][C:6]([C:7]([O:9][C:10]([CH3:13])([CH3:11])[CH3:12])=[O:8])=[C:5]([F:15])[CH:4]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 86703448Tert-butyl 5-chloro-2-fluoro-4-((1-(trifluoromethyl)-cyclohexyl)methoxy)benzoateHCID 86703484Tert-butyl 5-chloro-4-(cyclohexylmethoxy)-2-fluorobenzoate

Product 1

HCID 86703486Tert-butyl 4-(cyclohexylmethoxy)-5-cyclopropyl-2-fluorobenzoate

Procedure

Following the procedure as described in Example 158 step 3 and making variations as required to replace tert-butyl 5-chloro-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)-methoxy)benzoate with tert-butyl 5-chloro-4-(cyclohexylmethoxy)-2-fluorobenzoate, the title compound was obtained as colorless oil (13.73 g, 88%): MS (ES+) m/z 387.2 (M+39).

Sources & evidence

ORD record
ord-a8b831cdfd7841009fd7dd652f628d20
Source dataset
uspto-grants-2015_02
Patent number
US08952169B2

Reaction notes

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