HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 5-chloro-2-fluoro-4-((1-(trifluoromethyl)-cyclohexyl)methoxy)benzoate → Tert-butyl 4-(cyclohexylmethoxy)-5-cyclopropyl-2-fluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 5-chloro-2-fluoro-4-((1-(trifluoromethyl)-cyclohexyl)methoxy)benzoate | HCID 86703448 | — |
| Reactant | Tert-butyl 5-chloro-4-(cyclohexylmethoxy)-2-fluorobenzoate | HCID 86703484 | — |
| Product | Tert-butyl 4-(cyclohexylmethoxy)-5-cyclopropyl-2-fluorobenzoate | HCID 86703486 | — |
Reaction Steps
Following the procedure as described in Example 158 step 3 and making variations as required to replace tert-butyl 5-chloro-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)-methoxy)benzoate with tert-butyl 5-chloro-4-(cyclohexylmethoxy)-2-fluorobenzoate, the title compound was obtained as colorless oil (13.73 g, 88%): MS (ES+) m/z 387.2 (M+39).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952169B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-a8b831cdfd7841009fd7dd652f628d20 |
| Source note | uspto-grants-2015_02 |