Tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoate → 4-(Adamantan-2-ylmethoxy)-5-cyclopropyl-2-fluorobenzoic acid

HRID 1849646Notes

Reaction equation

HRID 1849646 reaction equation
C1(C2C(OCC3(C(F)(F)F)CCCCC3)=CC(F)=C(C=2)C(OC(C)(C)C)=O)CC1.[CH:30]12[CH2:39][CH:34]3[CH2:35][CH:36]([CH2:38][CH:32]([CH2:33]3)[CH:31]1[CH2:40][O:41][C:42]1[C:54]([CH:55]3[CH2:57][CH2:56]3)=[CH:53][C:45]([C:46]([O:48]C(C)(C)C)=[O:47])=[C:44]([F:58])[CH:43]=1)[CH2:37]2>>[CH:30]12[CH2:39][CH:34]3[CH2:35][CH:36]([CH2:38][CH:32]([CH2:33]3)[CH:31]1[CH2:40][O:41][C:42]1[C:54]([CH:55]3[CH2:56][CH2:57]3)=[CH:53][C:45]([C:46]([OH:48])=[O:47])=[C:44]([F:58])[CH:43]=1)[CH2:37]2

Participants

3

Reactant 2

HCID 86703449Tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoateHCID 86703508Tert-butyl 4-(adamantan-2-ylmethoxy)-5-cyclopropyl-2-fluorobenzoate

Product 1

HCID 867035094-(Adamantan-2-ylmethoxy)-5-cyclopropyl-2-fluorobenzoic acid

Procedure

Following the procedure as described in Example 158 step 4, and making variations as required to replace tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)-cyclohexyl)methoxy)benzoate with tert-butyl 4-(adamantan-2-ylmethoxy)-5-cyclopropyl-2-fluorobenzoate, the title compound was obtained as a colorless solid (0.79 g, 46%): MS (ES−) m/z 343.3 (M−1).

Sources & evidence

ORD record
ord-aa24fa353f784076a72bbac74e275a18
Source dataset
uspto-grants-2015_02
Patent number
US08952169B2

Reaction notes

Loading…