HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoate → 4-(Adamantan-2-ylmethoxy)-5-cyclopropyl-2-fluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoate | HCID 86703449 | — |
| Reactant | Tert-butyl 4-(adamantan-2-ylmethoxy)-5-cyclopropyl-2-fluorobenzoate | HCID 86703508 | — |
| Product | 4-(Adamantan-2-ylmethoxy)-5-cyclopropyl-2-fluorobenzoic acid | HCID 86703509 | — |
Reaction Steps
Following the procedure as described in Example 158 step 4, and making variations as required to replace tert-butyl 5-cyclopropyl-2-fluoro-4-((1-(trifluoromethyl)-cyclohexyl)methoxy)benzoate with tert-butyl 4-(adamantan-2-ylmethoxy)-5-cyclopropyl-2-fluorobenzoate, the title compound was obtained as a colorless solid (0.79 g, 46%): MS (ES−) m/z 343.3 (M−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952169B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-aa24fa353f784076a72bbac74e275a18 |
| Source note | uspto-grants-2015_02 |