Tetrabutylammonium Fluoride → HCID 86703581, compound

HRID 1849708Notes

Reaction equation

HRID 1849708 reaction equation
[N:1]1([S:5]([NH:8][C:9](=[O:39])[C:10]2[CH:15]=[C:14]([Cl:16])[C:13]([O:17][CH2:18][C:19]34[CH2:28][CH:23]5[CH2:24][CH:25]([CH2:27][C:21]([CH2:29][O:30][Si](C(C)(C)C)(C)C)([CH2:22]5)[CH2:20]3)[CH2:26]4)=[CH:12][C:11]=2[F:38])(=[O:7])=[O:6])[CH2:4][CH2:3][CH2:2]1.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[N:1]1([S:5]([NH:8][C:9](=[O:39])[C:10]2[CH:15]=[C:14]([Cl:16])[C:13]([O:17][CH2:18][C:19]34[CH2:28][CH:23]5[CH2:24][CH:25]([CH2:27][C:21]([CH2:29][OH:30])([CH2:22]5)[CH2:20]3)[CH2:26]4)=[CH:12][C:11]=2[F:38])(=[O:7])=[O:6])[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 86703582HCID 86703582, compound

Product 1

HCID 86703581HCID 86703581, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of N-(azetidin-1-ylsulfonyl)-4-((3-(((tert-butyldimethylsilyl)oxy)-methyl)adamantan-1-yl)methoxy)-5-chloro-2-fluorobenzamide (0.82 g, 1.36 mmol) in anhydrous tetrahydrofuran (24 mL) was treated with tetrabutylammonium fluoride (1.0 M solution in tetrahydrofuran,

Sources & evidence

ORD record
ord-859e4fe4be174407a54d188937a78823
Source dataset
uspto-grants-2015_02
Patent number
US08952169B2

Reaction notes

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