化工社化工社 化学情報印刷レポート · 研究参考用
Cyclopropylboronic acid → Tert-butyl 4-(adamantan-1-ylmethoxy)-5-cyclobutyl-2-fluorobenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclopropylboronic acid | HCID 2760897 | — |
| 反応物 | Cyclobutylboronic acid | HCID 16217845 | — |
| 反応物 | 2-Dicyclohexylphosphino-2',6'-diisopropoxybiphenyl | HCID 16217985 | — |
| 反応物 | Tri(cyclohexyl)phosphine tetrafluoroborate | HCID 20066521 | — |
| 反応物 | Tert-butyl 4-(adamantan-1-ylmethoxy)-5-chloro-2-fluorobenzoate | HCID 86702858 | — |
| 反応物 | Tert-butyl 5-chloro-4-((1-cyanocyclohexyl)methoxy)-2-fluorobenzoate | HCID 86703716 | — |
| 生成物 | Tert-butyl 4-(adamantan-1-ylmethoxy)-5-cyclobutyl-2-fluorobenzoate | HCID 86703727 | — |
反応手順
Following the procedure as described in Example 373 Step 1 and making non-critical variations to replace tert-butyl 5-chloro-4-((1-cyanocyclohexyl)-methoxy)-2-fluorobenzoate with tert-butyl 4-(adamantan-1-ylmethoxy)-5-chloro-2-fluorobenzoate, to replace cyclopropylboronic acid with cyclobutylboronic acid, and to replace tricyclohexylphosphine tetrafluoroborate with 2-dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl (RuPhos), the title compound was obtained as a colorless syrup containing ˜25% tert-butyl 4-(adamantan-1-ylmethoxy)-2-fluorobenzoate (1.01 g, 97%): MS (ES+) m/z 359.1 (M−55).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08952169B2 |
| 出典データセット | uspto-grants-2015_02 |
| ORD ID | ord-8344d59c44a646839044e54d9c1d4d75 |
| 出典メモ | uspto-grants-2015_02 |