反应详情

Following the procedure as described in Example 373 Step 1 and making non-critical variations to replace tert-butyl 5-chloro-4-((1-cyanocyclohexyl)-methoxy)-2-fluorobenzoate with tert-butyl 4-(adamantan-1-ylmethoxy)-5-chloro-2-fluorobenzoate, to replace cyclopropylboronic acid with cyclobutylboronic acid, and to replace tricyclohexylphosphine tetrafluoroborate with 2-dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl (RuPhos), the title compound was obtained as a colorless syrup containing ˜25% tert-butyl 4-(adamantan-1-ylmethoxy)-2-fluorobenzoate (1.01 g, 97%): MS (ES+) m/z 359.1 (M−55).