Tert-butyl 4-(bicyclo[4.1.0]heptan-1-ylmethoxy)-5-chloro-2-fluorobenzoate → HCID 86703740, compound

HRID 1849851Notes

Reaction equation

HRID 1849851 reaction equation
[C:1]12(COC3C(Cl)=CC(C(OC(C)(C)C)=O)=C(F)C=3)[CH2:7][CH:6]1CCCC2.Cl[C:26]1[C:27]([O:40][CH2:41][CH:42]2[CH2:48][CH2:47][CH:46]3[CH:44]([C:45]3([F:50])[F:49])[CH2:43]2)=[CH:28][C:29]([F:39])=[C:30]([CH:38]=1)[C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32]>>[CH:1]1([C:26]2[C:27]([O:40][CH2:41][CH:42]3[CH2:48][CH2:47][CH:46]4[CH:44]([C:45]4([F:50])[F:49])[CH2:43]3)=[CH:28][C:29]([F:39])=[C:30]([CH:38]=2)[C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 86703665Tert-butyl 4-(bicyclo[4.1.0]heptan-1-ylmethoxy)-5-chloro-2-fluorobenzoateHCID 86703741HCID 86703741, compound

Product 1

HCID 86703740HCID 86703740, compound

Procedure

Following the procedure as described in Example 342 Step 4 and making variations as required to replace tert-butyl 4-(bicyclo[4.1.0]heptan-1-ylmethoxy)-5-chloro-2-fluorobenzoate with tert-butyl 5-chloro-4-((7,7-difluorobicyclo[4.1.0]heptan-3-yl)methoxy)-2-fluorobenzoate, the title compound was obtained as oil (0.35 g, 48%): MS (ES+) m/z 341.07 (M−55).

Sources & evidence

ORD record
ord-186672c1bbd24c39b62e699dfd4452c9
Source dataset
uspto-grants-2015_02
Patent number
US08952169B2

Reaction notes

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