Methanesulfonamide → HCID 86703788, compound

HRID 1849910Notes

Reaction equation

HRID 1849910 reaction equation
[C:1]12([CH2:11][O:12][C:13]3[C:21]([F:22])=[CH:20][C:16]([C:17](O)=[O:18])=[C:15]([F:23])[C:14]=3[Cl:24])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[CH3:25][S:26]([NH2:29])(=[O:28])=[O:27]>>[C:1]12([CH2:11][O:12][C:13]3[C:21]([F:22])=[CH:20][C:16]([C:17]([NH:29][S:26]([CH3:25])(=[O:28])=[O:27])=[O:18])=[C:15]([F:23])[C:14]=3[Cl:24])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

Participants

3

Reactant 2

HCID 72879MethanesulfonamideHCID 86703787HCID 86703787, compound

Product 1

HCID 86703788HCID 86703788, compound

Procedure

The compound was prepared in a similar manner to step 2 of Example 412 from 4-(adamantan-1-ylmethoxy)-3-chloro-2,5-difluorobenzoic acid and methanesulfonamide. LCMS (Method D): RT=6.97 min, m/z: 434.1 [M+H]+. 1H NMR (400 MHz, DMSO-d6) δ 7.66 (dd, J=11.6, 6.6 Hz, 1H), 3.82 (d, J=2.0 Hz, 2H), 1.99 (s, 3H), 1.82-1.56 (m, 12H).

Sources & evidence

ORD record
ord-085022d06321406e8e958c68d58ed052
Source dataset
uspto-grants-2015_02
Patent number
US08952169B2

Reaction notes

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