HCID 86703795, compound → HCID 86703794, compound

HRID 1849915Notes

Reaction equation

HRID 1849915 reaction equation
[CH:1]1([C:4]2[C:5]([O:18][CH2:19][CH:20]3[CH2:25][CH2:24][CH2:23][C:22]([F:27])([F:26])[CH2:21]3)=[CH:6][C:7]([F:17])=[C:8]([CH:16]=2)[C:9]([O:11]C(C)(C)C)=[O:10])[CH2:3][CH2:2]1>ClCCl.FC(F)(F)C(O)=O>[CH:1]1([C:4]2[C:5]([O:18][CH2:19][CH:20]3[CH2:25][CH2:24][CH2:23][C:22]([F:27])([F:26])[CH2:21]3)=[CH:6][C:7]([F:17])=[C:8]([CH:16]=2)[C:9]([OH:11])=[O:10])[CH2:2][CH2:3]1

Participants

4

Reactant 1

HCID 86703795HCID 86703795, compound

Product 1

HCID 86703794HCID 86703794, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl 5-cyclopropyl-4-((3,3-difluorocyclohexyl)methoxy)-2-fluorobenzoate (191 mg) in dichloromethane (1.0 mL) and trifluoroacetic acid (0.5 mL) was stirred at 0° C. for 30 min then at rt for 3 h. The contents were concentrated. The residue was suspended in toluene and concentrated. The beige solid was dried under vacuum (162 mg).

Workup

  1. concentrationThe contents were concentrated
  2. concentrationconcentrated
  3. customThe beige solid was dried under vacuum (162 mg)

Sources & evidence

ORD record
ord-53d0e92f68d043bb96d8c957a9a2be17
Source dataset
uspto-grants-2015_02
Patent number
US08952169B2

Reaction notes

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