Sodium Hydroxide → HCID 131731332, compound

HRID 1849999Notes

Reaction equation

HRID 1849999 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:35]=[CH:34][C:13]([O:14][CH2:15][CH2:16][O:17][C:18](=[O:33])[CH2:19][CH2:20][C@H:21]([NH:25][C:26](=[O:32])[CH2:27][CH2:28][C:29]([OH:31])=[O:30])[C:22]([OH:24])=[O:23])=[CH:12][CH:11]=2)[C:5]([C:36]#[N:37])=[C:4]([S:38][CH2:39][C:40]2[N:41]=[C:42]([C:45]3[CH:50]=[CH:49][C:48]([Cl:51])=[CH:47][CH:46]=3)[S:43][CH:44]=2)[N:3]=1.[OH-].[Na+:53]>C(#N)C.O>[Na+:53].[Na+:53].[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([O:14][CH2:15][CH2:16][O:17][C:18](=[O:33])[CH2:19][CH2:20][C@H:21]([NH:25][C:26](=[O:32])[CH2:27][CH2:28][C:29]([OH:31])=[O:30])[C:22]([O-:24])=[O:23])=[CH:34][CH:35]=2)[C:5]([C:36]#[N:37])=[C:4]([S:38][CH2:39][C:40]2[N:41]=[C:42]([C:45]3[CH:50]=[CH:49][C:48]([Cl:51])=[CH:47][CH:46]=3)[S:43][CH:44]=2)[N:3]=1.[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([O:14][CH2:15][CH2:16][O:17][C:18](=[O:33])[CH2:19][CH2:20][C@H:21]([NH:25][C:26](=[O:32])[CH2:27][CH2:28][C:29]([OH:31])=[O:30])[C:22]([O-:24])=[O:23])=[CH:34][CH:35]=2)[C:5]([C:36]#[N:37])=[C:4]([S:38][CH2:39][C:40]2[N:41]=[C:42]([C:45]3[CH:50]=[CH:49][C:48]([Cl:51])=[CH:47][CH:46]=3)[S:43][CH:44]=2)[N:3]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 68750135HCID 68750135, compound

Product 1

HCID 131731332HCID 131731332, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

0.5 g (0.667 mmol) of the compound from example 9 is dissolved in 12.5 ml of acetonitrile and 62.5 ml of water, and 13 ml of 0.1N sodium hydroxide solution are added. After brief stirring, the mixture is lyophilized. After drying under high vacuum, 0.53 g (quant.) of the title compound remain.

Workup

  1. dry with materialAfter drying under high vacuum, 0.53 g (quant.) of the title compound

Sources & evidence

ORD record
ord-e754481843f64ba9bc77b93c11e45d2e
Source dataset
uspto-grants-2015_02
Patent number
US08957017B2

Reaction notes

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