Sodium Hydroxide → HCID 68295126, compound

HRID 1850076Notes

Reaction equation

HRID 1850076 reaction equation
[OH-].[Na+].[CH3:3][N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][N:11]2[CH:15]=[C:14](/[CH:16]=[CH:17]/[C:18]([O:20]C)=[O:19])[CH:13]=[N:12]2)[CH2:6][CH2:5]1>CO.C1COCC1>[CH3:3][N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][N:11]2[CH:15]=[C:14](/[CH:16]=[CH:17]/[C:18]([OH:20])=[O:19])[CH:13]=[N:12]2)[CH2:6][CH2:5]1

Participants

5

Reactant 2

HCID 14798Sodium Hydroxide2×HCID 68294314HCID 68294314, compound

Product 1

HCID 68295126HCID 68295126, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

An aqueous 3N sodium hydroxide solution (2 mL) was added to a solution of (E)-methyl 3-(1-((1-methylpiperidin-4-yl)methyl)-1H-pyrazol-4-yl)acrylate (220 mg) in MeOH (5 mL) and THF (3 mL) was added aq NaOH (3N, 2 mL) to saponify the methyl ester. Workup was performed as described in Example 12 to generate 209 mg of pure product (0.84 mmol, 100%).

Sources & evidence

ORD record
ord-e689be2c89ab4d73b4894ba3887a652b
Source dataset
uspto-grants-2015_02
Patent number
US08957066B2

Reaction notes

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