Hydrochloric Acid → HCID 86730155, compound

HRID 1850124Notes

Reaction equation

HRID 1850124 reaction equation
[CH2:1]([N:8]1[CH:12]=[C:11]([C@@H:13]([NH:15][S@@](C(C)(C)C)=O)[CH3:14])[C:10]([CH3:22])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:23]>O1CCOCC1>[ClH:23].[CH2:1]([N:8]1[CH:12]=[C:11]([C@@H:13]([NH2:15])[CH3:14])[C:10]([CH3:22])=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86730153HCID 86730153, compound

Product 1

HCID 86730155HCID 86730155, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

(R)—N—((S)-1-(1-benzyl-3-methyl-1H-pyrazol-4-yl)ethyl)-2-methylpropane-2-sulfinamide was dissolved in dioxane (5 ml) and 4N HCl in dioxane (1.2 ml, 10 eq.) was added. Stirred 1H at room temperature. The solvents were removed and co-yapped twice with CH2Cl2. Some t-butyl observed by NMR. Resubmitted to reaction conditions and work-up to give title compound.

Workup

  1. customThe solvents were removed
  2. customResubmitted to reaction conditions

Sources & evidence

ORD record
ord-91c43762a9a4455dbf357b2df03e78f4
Source dataset
uspto-grants-2015_02
Patent number
US08957068B2

Reaction notes

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