HRID1850184

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID43810892

tert-Butyl 3,8-diazabicyclo[4.2.0]octane-8-carboxylate

C11H20N2O2

结构：CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(C=O)cc2)n1

HCID86730159

未命名化合物

PRODUCTS

生成物

结构：CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(CN3CCC4CN(C(=O)OC(C)(C)C)C4C3)cc2)n1

HCID86730210

未命名化合物

PROCEDURE

实验过程

Title compound was prepared as a white solid (64 mg, 58.1% yield), with procedures similar to those used to prepare Intermediate 128, but utilizing 4-((S)-1-(4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-ylamino)ethyl)benzaldehyde and tert-butyl 3,8-diazabicyclo[4.2.0]octane-8-carboxylate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d95d2208c36443ae90a0b5399f3c1271
来源数据集: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08957068B2
来源说明: uspto-grants-2015_02

反应 SMILES

[CH:1]([C@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:10]1[CH:15]=[CH:14][N:13]=[C:12]([NH:16][C@H:17]([C:19]2[CH:26]=[CH:25][C:22]([CH:23]=O)=[CH:21][CH:20]=2)[CH3:18])[N:11]=1)([CH3:3])[CH3:2].[CH:27]12[N:34]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:33][CH:32]1[CH2:31][CH2:30][NH:29][CH2:28]2>>[CH:1]([C@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:10]1[CH:15]=[CH:14][N:13]=[C:12]([NH:16][C@H:17]([C:19]2[CH:26]=[CH:25][C:22]([CH2:23][N:29]3[CH2:30][CH2:31][CH:32]4[CH:27]([N:34]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:33]4)[CH2:28]3)=[CH:21][CH:20]=2)[CH3:18])[N:11]=1)([CH3:2])[CH3:3]