HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3,8-diazabicyclo[4.2.0]octane-8-carboxylate → tert-butyl 3-(4-((S)-1-(4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-ylamino)ethyl)benzyl)-3,8-diazabicyclo[4.2.0]octane-8-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3,8-diazabicyclo[4.2.0]octane-8-carboxylate | HCID 43810892 | — |
| Reactant | 4-((S)-1-(4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-ylamino)ethyl)benzaldehyde | HCID 86730159 | — |
| Product | tert-butyl 3-(4-((S)-1-(4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-ylamino)ethyl)benzyl)-3,8-diazabicyclo[4.2.0]octane-8-carboxylate | HCID 86730210 | — |
Reaction Steps
Title compound was prepared as a white solid (64 mg, 58.1% yield), with procedures similar to those used to prepare Intermediate 128, but utilizing 4-((S)-1-(4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-ylamino)ethyl)benzaldehyde and tert-butyl 3,8-diazabicyclo[4.2.0]octane-8-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957068B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-d95d2208c36443ae90a0b5399f3c1271 |
| Source note | uspto-grants-2015_02 |