Hydrochloride methanol → HCID 67469212, compound

HRID 1850247Notes

Reaction equation

HRID 1850247 reaction equation
C(OC([N:8]1[CH2:11][CH:10]([C:12]2[C:17]([O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[O:25][CH3:26])=[N:16][CH:15]=[CH:14][N:13]=2)[CH2:9]1)=O)(C)(C)C.[ClH:27].CO>>[ClH:27].[NH:8]1[CH2:9][CH:10]([C:12]2[C:17]([O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[O:25][CH3:26])=[N:16][CH:15]=[CH:14][N:13]=2)[CH2:11]1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 58547489HCID 58547489, compound

Product 1

HCID 67469212HCID 67469212, compoundYield 100%

Procedure

To a solution of 4 N HCl/MeOH (10 mL) was added compound (13) (80 mg, 0.22 mmol) at 0° C. The resulting mixture was stirred at RT for 1 h. The mixture was concentrated under reduced pressure to give (14) (65 mg, yield 100%), which was used for the next step without further purification. ESI-MS (M+1): 258 calc. for C14H15N3O2 257.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f389f51599c144dc9b0a3f3a894ec6af
Source dataset
uspto-grants-2015_02
Patent number
US08957073B2

Reaction notes

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