反应详情

Na2CO3 (0.64 g, 6.07 mmol) was added to a solution of (17) (1.9 g, 6.07 mmol) in 20 mL MeOH. The reaction mixture was heated to reflux for 14 h and then cooled to RT. 1N HCl was added to the solution and the reaction mixture was stirred for 0.5 hour. The mixture was extracted with EA. The organic phase was washed with brine, dried over Na2SO4 and evaporated to give the title compound (0.89 g, yield 83%). ESI-MS (M+1): 177 calc. for C9H8N2O2 176.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 14 h
3. extractionThe mixture was extracted with EA
4. washThe organic phase was washed with brine
5. dry with materialdried over Na2SO4
6. customevaporated