Hydrochloride methanol → [1-(3-Piperidin-4-YL-pyrazin-2-YL)-piperidin-4-YL]-methanol hydrochloride

HRID 1850261Notes

Reaction equation

HRID 1850261 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:19]([N:20]3[CH2:25][CH2:24][CH:23]([CH2:26][OH:27])[CH2:22][CH2:21]3)=[N:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:28].CO>>[ClH:28].[NH:8]1[CH2:9][CH2:10][CH:11]([C:14]2[C:19]([N:20]3[CH2:25][CH2:24][CH:23]([CH2:26][OH:27])[CH2:22][CH2:21]3)=[N:18][CH:17]=[CH:16][N:15]=2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 585475224-[3-(4-Hydroxymethyl-piperidin-1-YL)-pyrazin-2-YL]-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 67469206[1-(3-Piperidin-4-YL-pyrazin-2-YL)-piperidin-4-YL]-methanol hydrochlorideYield 98.72%

Procedure

A solution of 4-[3-(4-hydroxymethyl-piperidin-1-yl)-pyrazin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (40) (376 mg, 1 mmol) in 4N HCl/MeOH (20 mL) was stirred at RT for 30 min. The reaction mixture was concentrated to give (41) (308 mg, 0.98 mmol, yield 98.72%).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-6116bff24407416e870e2b48a63eda87
Source dataset
uspto-grants-2015_02
Patent number
US08957073B2

Reaction notes

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