HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloride methanol → [1-(3-Piperidin-4-YL-pyrazin-2-YL)-piperidin-4-YL]-methanol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | 4-[3-(4-Hydroxymethyl-piperidin-1-YL)-pyrazin-2-YL]-piperidine-1-carboxylic acid tert-butyl ester | HCID 58547522 | — |
| Product | [1-(3-Piperidin-4-YL-pyrazin-2-YL)-piperidin-4-YL]-methanol hydrochloride | HCID 67469206 | 98.72% |
Reaction Steps
A solution of 4-[3-(4-hydroxymethyl-piperidin-1-yl)-pyrazin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (40) (376 mg, 1 mmol) in 4N HCl/MeOH (20 mL) was stirred at RT for 30 min. The reaction mixture was concentrated to give (41) (308 mg, 0.98 mmol, yield 98.72%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957073B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-6116bff24407416e870e2b48a63eda87 |
| Source note | uspto-grants-2015_02 |