Tert-butyl 3-(3-chloropyrazin-2-yl)azetidine-1-carboxylate → 2-(Azetidin-3-YL)-3-chloropyrazine hydrochloride

HRID 1850266Notes

Reaction equation

HRID 1850266 reaction equation
[Cl:1][C:2]1[C:3]([CH:8]2[CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]2)=[N:4][CH:5]=[CH:6][N:7]=1>Cl.CO>[ClH:1].[NH:10]1[CH2:11][CH:8]([C:3]2[C:2]([Cl:1])=[N:7][CH:6]=[CH:5][N:4]=2)[CH2:9]1

Participants

3

Reactant 1

HCID 59351411Tert-butyl 3-(3-chloropyrazin-2-yl)azetidine-1-carboxylate

Product 1

HCID 717437842-(Azetidin-3-YL)-3-chloropyrazine hydrochlorideYield 199%

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Procedure

A solution of compound (7) (540 mg, 2.0 mmol) in 2N HCl/MeOH (20 mL) was stirred at RT for 30 min according to Preparation 2. The reaction mixture was concentrated to give compound (8) (440 mg, 1.99 mmol, yield 99.7%).

Workup

  1. customaccording to Preparation 2
  2. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-50e3544c6fd54e1ea492f6578576ab0b
Source dataset
uspto-grants-2015_02
Patent number
US08957073B2

Reaction notes

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