HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-(3-chloropyrazin-2-yl)azetidine-1-carboxylate → 2-(Azetidin-3-YL)-3-chloropyrazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-(3-chloropyrazin-2-yl)azetidine-1-carboxylate | HCID 59351411 | — |
| Solvent | Hydrochloride methanol | HCID 21893726 | — |
| Product | 2-(Azetidin-3-YL)-3-chloropyrazine hydrochloride | HCID 71743784 | 199% |
Reaction Steps
A solution of compound (7) (540 mg, 2.0 mmol) in 2N HCl/MeOH (20 mL) was stirred at RT for 30 min according to Preparation 2. The reaction mixture was concentrated to give compound (8) (440 mg, 1.99 mmol, yield 99.7%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957073B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-50e3544c6fd54e1ea492f6578576ab0b |
| Source note | uspto-grants-2015_02 |