1-BOC-4-DIMETHYLCARBAMOYLPIPERIDINE → N,N-Dimethylpiperidine-4-carboxamide--hydrogen chloride (1/1)

HRID 1850276Notes

Reaction equation

HRID 1850276 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14](=[O:18])[N:15]([CH3:17])[CH3:16])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:19].CO>>[ClH:19].[CH3:16][N:15]([CH3:17])[C:14]([CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:18]

Participants

3

Reactant 2

HCID 110215051-BOC-4-DIMETHYLCARBAMOYLPIPERIDINEHCID 21893726Hydrochloride methanol

Product 1

HCID 19872414N,N-Dimethylpiperidine-4-carboxamide--hydrogen chloride (1/1)Yield 99.9%

Procedure

A solution of 4-dimethylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester (66) (220 mg, 0.85 mmol) in 4N HCl/MeOH (20 mL) was stirred at RT for 30 min. The reaction mixture was concentrated to give the product piperidine-4-carboxylic acid dimethylamide hydrochloride (67) (163 mg, 0.85 mmol, yield 99.9%).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-7d86d54b22694a46929d1d760bb09730
Source dataset
uspto-grants-2015_02
Patent number
US08957073B2

Reaction notes

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