HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-BOC-4-DIMETHYLCARBAMOYLPIPERIDINE → N,N-Dimethylpiperidine-4-carboxamide--hydrogen chloride (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-BOC-4-DIMETHYLCARBAMOYLPIPERIDINE | HCID 11021505 | — |
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Product | N,N-Dimethylpiperidine-4-carboxamide--hydrogen chloride (1/1) | HCID 19872414 | 99.9% |
Reaction Steps
A solution of 4-dimethylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester (66) (220 mg, 0.85 mmol) in 4N HCl/MeOH (20 mL) was stirred at RT for 30 min. The reaction mixture was concentrated to give the product piperidine-4-carboxylic acid dimethylamide hydrochloride (67) (163 mg, 0.85 mmol, yield 99.9%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957073B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-7d86d54b22694a46929d1d760bb09730 |
| Source note | uspto-grants-2015_02 |