Hydrochloride methanol → HCID 67468031, compound

HRID 1850278Notes

Reaction equation

C(OC([N:8]1[CH2:11][CH:10]([C:12]2[C:21]([C:22]3[CH:23]=[C:24]([CH3:28])[CH:25]=[CH:26][CH:27]=3)=[N:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)[CH2:9]1)=O)(C)(C)C.[ClH:29].CO>>[ClH:29].[NH:8]1[CH2:11][CH:10]([C:12]2[C:21]([C:22]3[CH:23]=[C:24]([CH3:28])[CH:25]=[CH:26][CH:27]=3)=[N:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)[CH2:9]1

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 58547240HCID 58547240, compound

Product 1

HCID 67468031HCID 67468031, compoundYield 98.8%

Procedure

A solution of 3-(3-m-tolyl-quinoxalin-2-yl)-azetidine-1-carboxylic acid tert-butyl ester (69) (637 mg, 1.7 mmol) in 4N HCl/MeOH (25 mL) was stirred at RT for 30 min. The reaction mixture was concentrated to give 2-azetidin-3-yl-3-m-tolyl-quinoxaline hydrochloride (70) (523 mg, 1.68 mmol, yield 98.8%).

Workup

concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record: ord-bf3128f0f85643afa42a96af224f656a
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08957073B2

Reaction notes

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