Hydrochloride methanol → HCID 67469104, compound

HRID 1850281Notes

Reaction equation

HRID 1850281 reaction equation
[N:1]1([C:7]2[C:8]([CH:13]3[CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14]3)=[N:9][CH:10]=[CH:11][N:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:24].CO>>[ClH:24].[NH:15]1[CH2:16][CH:13]([C:8]2[C:7]([N:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)=[N:12][CH:11]=[CH:10][N:9]=2)[CH2:14]1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 58547146HCID 58547146, compound

Product 1

HCID 67469104HCID 67469104, compoundYield 99%

Procedure

A solution of 3-(3-piperidin-1-yl-pyrazin-2-yl)-azetidine-1-carboxylic acid tert-butyl ester (74) (191 mg, 0.6 mmol) in 4N HCl/MeOH (13 mL) was stirred at RT for 30 min. The reaction mixture was concentrated to give (75) (150 mg, 0.59 mmol, yield 99%). ESI-MS (M+1): 219 calc. for C12H18N4 218

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-566900c3d63243b88dc8ea8a594a21dc
Source dataset
uspto-grants-2015_02
Patent number
US08957073B2

Reaction notes

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