Hydrochloride methanol → HCID 86660166, compound

HRID 1850283Notes

Reaction equation

C(OC([N:8]1[CH2:11][CH:10]([C:12]2[C:17]([N:18]3[CH2:23][CH2:22][CH:21]([CH2:24][OH:25])[CH2:20][CH2:19]3)=[CH:16][C:15]([F:26])=[CH:14][N:13]=2)[CH2:9]1)=O)(C)(C)C.[ClH:27].CO>>[ClH:27].[NH:8]1[CH2:11][CH:10]([C:12]2[C:17]([N:18]3[CH2:19][CH2:20][CH:21]([CH2:24][OH:25])[CH2:22][CH2:23]3)=[CH:16][C:15]([F:26])=[CH:14][N:13]=2)[CH2:9]1

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 58547336HCID 58547336, compound

Product 1

HCID 86660166HCID 86660166, compoundYield 98%

Procedure

A mixture of 3-(5′-fluoro-4-hydroxymethyl-3,4,5,6-tetrahydro-2H-[1,3′]bipyridinyl-2′-yl)-azetidine-1-carboxylic acid tert-butyl ester (76) (490 mg, 1.34 mmol) in 4 M HCl/MeOH solution (10 mL) was stirred at RT for 30 min. Then the solvent was evaporated at 40° C. to give (77) (392 mg, 1.3 mmol, 98% yield) as a yellow solid. ESI-MS (M+1): 266 calc. for C14H20FN3O 265.

Workup

customThen the solvent was evaporated at 40° C.

Sources & evidence

ORD record: ord-6924fadf26584df08056641c6d81e536
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08957073B2

Reaction notes

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