Hydrochloric Acid → HCID 67997282, compound

HRID 1850296Notes

Reaction equation

HRID 1850296 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:19]([N:20]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:22][CH2:21]3)=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:29]>CO>[ClH:29].[N:20]1([C:19]2[C:14]([CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[N:15][CH:16]=[CH:17][CH:18]=2)[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58547567HCID 58547567, compound

Product 1

HCID 67997282HCID 67997282, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 3-(2,3-dihydro-indol-1-yl)-3′,4′,5′,6′-tetrahydro-2′H-[2,4′]bipyridinyl-1′-carboxylic acid tert-butyl ester (95) (100 mg, 0.29 mmol) was added 4 M HCl in MeOH (20 mL). The reaction mixture was stirred at RT for 1 h. Then it was concentrated to give 3-(2,3-dihydro-indol-1-yl)-1′,2′,3′,4′,5′,6′-hexahydro-[2,4′]bipyridinyl hydrochloride (96) (0.083 g, 0.29 mmol, 100% yield) which was used in the next step without further purification.

Workup

  1. concentrationThen it was concentrated

Sources & evidence

ORD record
ord-05084b4c8c8a4f238370f1231e3cf0e1
Source dataset
uspto-grants-2015_02
Patent number
US08957073B2

Reaction notes

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