Hydrochloride methanol → HCID 86660167, compound

HRID 1850297Notes

Reaction equation

HRID 1850297 reaction equation
C(OC([N:8]1[CH2:11][CH:10]([C:12]2[C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)[CH2:9]1)=O)(C)(C)C.[ClH:28].CO>>[ClH:28].[NH:8]1[CH2:9][CH:10]([C:12]2[C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)[CH2:11]1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 58546744HCID 58546744, compound

Product 1

HCID 86660167HCID 86660167, compoundYield 100%

Procedure

A mixture of 3-(3-phenyl-pyridin-2-yl)-azetidine-1-carboxylic acid tert-butyl ester (99) (216 mg, 0.60 mmol) in 4 M HCl/MeOH solution (10 mL) was stirred at RT. for 30 min. Then the solvent was evaporated at 40° C. to give 2-azetidin-3-yl-3-phenyl-pyridine (100) (177 mg, 100% yield) as a yellow solid.

Workup

  1. customThen the solvent was evaporated at 40° C.

Sources & evidence

ORD record
ord-2bca621cec9445019b9b92485849e456
Source dataset
uspto-grants-2015_02
Patent number
US08957073B2

Reaction notes

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