Hydrochloric Acid → HCID 67469116, compound

HRID 1850307Notes

Reaction equation

HRID 1850307 reaction equation
[ClH:1].C(OC([N:9]1[CH2:12][CH:11]([C:13]2[C:18]([CH:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[N:17][CH:16]=[CH:15][N:14]=2)[CH2:10]1)=O)(C)(C)C>CO>[ClH:1].[NH:9]1[CH2:12][CH:11]([C:13]2[C:18]([CH:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[N:17][CH:16]=[CH:15][N:14]=2)[CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58546753HCID 58546753, compound

Product 1

HCID 67469116HCID 67469116, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 4 N HCl in MeOH (10 mL) was added 3-[3-(Tetrahydro-pyran-4-yl)-pyrazin-2-yl]-azetidine-1-carboxylic acid tert-butyl ester (116) (897 mg, 2.81 mmol) at 0° C. and the resulting mixture was stirred at RT for 1 h. The mixture was concentrated under reduced pressure to give 2-azetidin-3-yl-3-(tetrahydro-pyran-4-yl)-pyrazine hydrochloride (117) (716 mg, yield 100%) which was used for the next step without further purification. ESI-MS (M+1): 220 calc. for C12H17N3O 219.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-24b1221d658248669c08edc0137ec738
Source dataset
uspto-grants-2015_02
Patent number
US08957073B2

Reaction notes

Loading…