反应详情

To a solution of (124) (2.0 g, 6.6 mmol) in MeCN (20 mL) were added 2,4-dimethoxy-benzylamine (1.2 g, 7.3 mmol) and Et3N (2.0 g, 19.8 mmol). The solution was allowed to heat at reflux for 12 h. The reaction mixture was then filtered through a pad of silica (washing with 30 percent EtOAc:Petrol ether), and the solvent removed under reduced pressure to give the product (125) (1.2 g, 4.3 mmol, yield: 65%). ESI-MS (M+1): 278 calc. for C16H23NO3 277.

1. temperatureto heat
2. temperatureat reflux for 12 h
3. filtrationThe reaction mixture was then filtered through a pad of silica (washing with 30 percent EtOAc:Petrol ether)
4. customthe solvent removed under reduced pressure