HCID 58547508, compound → HCID 58547425, compound

HRID 1850340Notes

Reaction equation

HRID 1850340 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]([N:12]1[CH2:15][CH:14]([C:16]2[C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:20][N:19]=[C:18](Cl)[N:17]=2)[CH2:13]1)=[O:11]>CO.[Pd]>[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]([N:12]1[CH2:15][CH:14]([C:16]2[C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:20][N:19]=[CH:18][N:17]=2)[CH2:13]1)=[O:11]

Participants

4

Reactant 1

HCID 58547508HCID 58547508, compound

Product 1

HCID 58547425HCID 58547425, compoundYield 57.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of (1H-Benzoimidazol-2-yl)-[3-(2-chloro-5-phenyl-pyrimidin-4-yl)-azetidin-1-yl]-methanone (102 mg, 0.28 mmol) in MeOH (10 mL) was added Pd/C (100 mg). The reaction solution was stirred at RT overnight under H2 atmosphere. The mixture was filtered and concentrated to give the product (51 mg, 0.16 mmol, yield: 55%).

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-c8f932d3b1ab4d53a652c3e7509f12a0
Source dataset
uspto-grants-2015_02
Patent number
US08957073B2

Reaction notes

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