1-Bromo-4-ethylbenzene → HCID 59484997, compound

HRID 1850470Notes

Reaction equation

HRID 1850470 reaction equation
[CH3:1][O:2][C:3]1[C:11]2[O:10][C:9]([CH3:13])([CH3:12])[CH2:8][C:7]=2[C:6]([CH3:14])=[C:5]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[C:4]=1[CH3:21].Br[C:23]1[CH:28]=[CH:27][C:26]([CH2:29][CH3:30])=[CH:25][CH:24]=1>>[CH2:29]([C:26]1[CH:27]=[CH:28][C:23]([N:18]2[CH2:19][CH2:20][N:15]([C:5]3[C:4]([CH3:21])=[C:3]([O:2][CH3:1])[C:11]4[O:10][C:9]([CH3:13])([CH3:12])[CH2:8][C:7]=4[C:6]=3[CH3:14])[CH2:16][CH2:17]2)=[CH:24][CH:25]=1)[CH3:30]

Participants

3

Reactant 2

HCID 153131-Bromo-4-ethylbenzeneHCID 66760421HCID 66760421, compound

Product 1

HCID 59484997HCID 59484997, compoundYield 25%

Procedure

By using 1-(7-methoxy-2,2,4,6-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine (400 mg, 1.38 mmol) synthesized in Reference example 96 and 1-bromo-4-ethylbenzene (383 mg, 2.07 mmol), the reaction was carried out in the same manner as Reference example 59 to synthesize the title compound 133 mg (yield 25%). Melting point was 157 to 160° C. (hexane-ethyl acetate).

Sources & evidence

ORD record
ord-75442eca78854e77ab9918a40b699f70
Source dataset
uspto-grants-2015_02
Patent number
US08957069B2

Reaction notes

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