2-Bromo-1,3,4-thiadiazole → HCID 59485059, compound

HRID 1850486Notes

Reaction equation

HRID 1850486 reaction equation
[CH3:1][CH:2]1[CH2:6][C:5]2[C:7]([CH3:19])=[C:8]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[C:9]([CH3:12])=[C:10]([CH3:11])[C:4]=2[O:3]1.Br[C:21]1[S:22][CH:23]=[N:24][N:25]=1>>[CH3:1][CH:2]1[CH2:6][C:5]2[C:7]([CH3:19])=[C:8]([N:13]3[CH2:14][CH2:15][N:16]([C:21]4[S:22][CH:23]=[N:24][N:25]=4)[CH2:17][CH2:18]3)[C:9]([CH3:12])=[C:10]([CH3:11])[C:4]=2[O:3]1

Participants

3

Reactant 2

HCID 27951982-Bromo-1,3,4-thiadiazoleHCID 667598101-(2,4,6,7-Tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine

Product 1

HCID 59485059HCID 59485059, compoundYield 14%

Procedure

By using 1-(2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine (130 mg, 0.50 mmol) synthesized in Reference example 56 and 2-bromo-1,3,4-thiadiazole (165 mg, 1.0 mmol), the reaction was carried out in the same manner as Example 23 to synthesis the title compound 24 mg (yield 14%).

Sources & evidence

ORD record
ord-4c1f131429a4401696956c9a433fd721
Source dataset
uspto-grants-2015_02
Patent number
US08957069B2

Reaction notes

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