HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-nitropyridine → HCID 67355839, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-nitropyridine | HCID 817620 | — |
| Reactant | tert-Butyl 2-oxo-3,8-diazabicyclo[3.2.1]octane-8-carboxylate | HCID 16638505 | — |
| Product | HCID 67355839 | HCID 67355839 | 153.6% |
Reaction Steps
Following general N—C coupling procedure 1, 5-bromo-2-nitropyridine (110 mg, 0.542), was combined with 2-Oxo-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (135 mg, 0.596 mg), which after purification silica gel chromatography gave 3-(6-Nitro-pyridin-3-yl)-2-oxo-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (290 mg, 81%). MS m/z 349.0 (MH+), and was used directly as is without further characterization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957074B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-45a2cde6055041beb8857881393defdb |
| Source note | uspto-grants-2015_02 |