反应详情

A mixture of 5-bromo-3-methyl-4-nitro-isothiazole (200 mg, 0.8967 mmol), (1,3-dioxoisoindolin-2-yl)potassium (174.4 mg, 0.9415 mmol) in dry DMF (2 mL) was stirred at RT overnight. The mixture was quenched by the addition of methanol, stirred at RT for 1 h, then the reaction mixture was concentrated in vacuo. The residue was triturated in a small volume of dry MeOH. The precipitate was collected by filtration and dried in vacuo, yielding methyl 2-((3-methyl-4-nitroisothiazol-5-yl)carbamoyl)benzoate as a pale yellow solid. (165 mg, 57%) MS (ES+) 322.1.

1. customThe mixture was quenched by the addition of methanol
2. stirringstirred at RT for 1 h
3. concentrationthe reaction mixture was concentrated in vacuo
4. customThe residue was triturated in a small volume of dry MeOH
5. filtrationThe precipitate was collected by filtration
6. customdried in vacuo