Trifluoroacetic acid → 2-(4-(Benzyloxy)-2-chlorophenyl)acetic acid

HRID 1850720Notes

Reaction equation

HRID 1850720 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([O:18]C(C)(C)C)=[O:17])=[C:11]([Cl:23])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([OH:18])=[O:17])=[C:11]([Cl:23])[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 70856298Tert-butyl [4-(benzyloxy)-2-chlorophenyl]acetate

Product 1

HCID 42417462-(4-(Benzyloxy)-2-chlorophenyl)acetic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl [4-(benzyloxy)-2-chlorophenyl]acetate (1.0 g, 3.00 mmol) in DCM (8 ml) was treated with TFA (6.94 ml, 90 mmol) and the mixture stirred at RT for 30 min. The volatiles were removed in vacuo to afford the title compound. LC/MS (m/z): 299 (M+Na)+.

Workup

  1. customThe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-ae42d57c9a4044cda97363be101f0331
Source dataset
uspto-grants-2015_02
Patent number
US08957062B2

Reaction notes

Loading…