Hydroxylamine → HCID 178513430, compound

HRID 1850795Notes

Reaction equation

HRID 1850795 reaction equation
[OH:1][CH2:2][CH2:3][C@@H:4]1[CH2:6][C@@H:5]1[CH:7]1[CH2:12][CH2:11][N:10]([C:13]#[N:14])[CH2:9][CH2:8]1.[NH2:15][OH:16]>C(O)C>[OH:16][NH:15][C:13]([N:10]1[CH2:11][CH2:12][CH:7]([C@H:5]2[CH2:6][C@H:4]2[CH2:3][CH2:2][OH:1])[CH2:8][CH2:9]1)=[NH:14]

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 867111834-((1R,2S)-2-(2-hydroxyethyl)cyclopropyl)piperidine-1-carbonitrile

Product 1

HCID 178513430HCID 178513430, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
65 °C

Procedure

4-((1R,2S)-2-(2-hydroxyethyl)cyclopropyl)piperidine-1-carbonitrile (4.1 g, 21.10 mmol) was dissolved in Ethanol (60 ml) and hydroxylamine (5.17 ml, 84 mmol) (50% water solution) was added dropwise. The mixture was heated at 65° C. for 1 h. The mixture was evaporated to afford the desired product which was used for the next step without further purification. Rf was 0 @ 70% EtOAc in hexanes (blue spot on CAM stain)

Workup

  1. customThe mixture was evaporated

Sources & evidence

ORD record
ord-6daab790a6a64dd1bb0556ab5b31f87a
Source dataset
uspto-grants-2015_02
Patent number
US08957062B2

Reaction notes

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